Preliminary Antinociceptive Studies of Methanol Extract of Euphorbia milli

The crude methanolic extract of aerial parts of Euphorbia milli was tested for its antinociceptive property. The antinociceptive effect was evaluated usin chemical (acetic acid) induced pain paradigm. The acetic acid induced writhing was significantly attenuated by the crude methanolic extract. The mean number of writhing reduction of the crude methanolic extract was 12.34, 32.54 and 71.44 % at the tested doses of 50, 100 and 150 mg/kg respectively. The percent effect of diclofenac sodium was 82.34% was nearest to our tested sample. The crude methanolic extract demonstrated a dose and time dependent effect.